Selecting a region changes the language and/or content on. You will likely A) mess up your computer, or B) mess up GIMP, or other software.
None of this is a good idea to be honest.
It will affect all software which uses them. If you are unsure if your EULA permits adding a font to Creative Cloud and its use through this feature, contact the foundry, designer, or reseller from whom you purchased your EULA. Deleting fonts from Windows is not a good idea. As with any font you install, your font EULA may prohibit some uses. Through Creative Cloud, you’ll be able to select your font from the Fonts menu in Adobe applications and services for desktop publishing - as if you had installed the font yourself. Adobe will not distribute or make your font available to any other user. When you add a font to Creative Cloud, Adobe will not modify it, but we will store the font in Creative Cloud, and may make and distribute copies for your use on computers and other devices where you log in with your Adobe ID. To help you decide, here are some of the ways that fonts are managed when they are added to Creative Cloud with this feature. Make sure to read and understand the end user license agreement (EULA) that describes the permitted rights and uses for your font, and to avoid any feature or workflow that violates your EULA - or abstain from using this feature entirely.